The Science – Nyoteni

The Science Of Our Cream

Harnessing the power of cell-derived molecules

The future of regenerative medicine isn’t just about the cell; it’s about the regenerative potential of the cell-secreted proteins.

Our team is committed to help lead the way by harnessing the power of cell-derived proteins and nano vesicles from immunologically privileged tissues to develop first-of-its kind 100% pure and natural product offerings for advanced alternative therapies.

The Nature of Exosomes

Micro-vesicles (30-150m) that are involved in cell communication.
This is a new frontier in regenerative medicine. These exosomes have been recently discovered to be involved in direct cell signaling.
The exosomes are isolated and purified using proprietary processing. The unique benefit to these exosomes is that they bring a wide array of Growth Factors to stimulate and modulate many processes within the healing cascade.

Exosomes are not cells but are micro-vesicles, which are about 1/1,000th the size of a cell and contain no nucleus or DNA. They can be regarded as the purest form of cellular therapy available, because their function is to direct tissue and wound healing by activating the patient’s own regenerative cell response.

Stem cells and stem cell therapy work by paracrine signaling (local cell-to-cell communication to induce changes in nearby cells) to create the appropriate healing environment to restore tissue. The exosomes are those paracrine signals that can be delivered immediately. As the technology and discovery of new methods of treating patients has evolved, the science shows that the optimal way to provide true “stem cell therapy” is to directly provide the signals as its’ own therapy and avoid potential issues with delivering and keeping transplanted cells alive.

Exosomes, found in healthy tissue, have shown 1000+ Growth Factors Proteins to help modulate the inflammatorv healing process. This is accomplished by activating and recruiting the patients’ own cells to the area, revascularizing the area and reducing the inflammatory response to allow natural healing.

Cardinal Features of Exosomes
30 - 150 nm particles	Released by nearly all cell types
Present in all body fluids	Loaded with miRs and other bioactive contents
Payload very cell-specific

Following FDA approval guidelines

The recovery is performed by American Association of Tissue Bank (AATB) accredited technicians utilizing aseptic technique.

Click below to see what we test for!

We continue to “exceed” industry standards for testing. All of our products are sent for sterility, endotoxin, and environmental testing by a third-party laboratory that is a global leader in pharmaceutical, cosmetic, and environmental testing arena.

USP 71 Sterility Guidelines (All Fungus, Mold, Yeast, Bacteria) in accordance with AATB and FDA guidelines.
Endotoxin guidelines and environmental testing in accordance with AATB and FDA
guidelines.
Viruses, blood, and tissue borne pathogens in accordance with AATB and FDA guidelines including HIV, HBsAg, HCV, HBc Total, HTLV I/II, RPR, HIV/HCV/HBV Ultrio, WNV NAT, CMV Ab, Zika NAT, Lyme Disease, Epstein-Barr Virus, E.coli, Candida, and COVID-1

How are the exosomes processed? And are they safe?

Tissue is processed according to the rules and regulation of the American
Association of Tissue Banks (AATB). A thorough checklist of donor’s medical history, social history, and a blood test is performed. If donor is deemed an acceptable donor according to prevailing rules of the AATB, then tissue is collected at the lab. Once at the lab a tissue sample is sent to a 3rd party independent FDA registered lab for testing according to United States Pharmacopeia rule 71 (U.S.P. 71), which is a test for known communicable diseases. While that test is taking
place, tissue is then processed and red blood cell products are removed. A sample of the finished exosome product is then sent to a different 3rdparty independent FDA registered lab for sterility testing.
Only after both lab reports come back as “clean” and have passed the regulatory requirements, is the
processed exosome tissue product available for distribution.

Why is our cream in an airless pump bottle presentation?

Benefits:

• Prevents air entry: No air enters the container, reducing oxidation and contamination.
• Eliminates bacteria growth: No bacteria, mold, or yeast can grow in the absence of air.
• Minimizes moisture exposure: The airless design reduces moisture entry, preventing hydrolysis.
• Blocks light exposure: Our frosted bottle shields our formulation from UV light degradation.
• Maintains product sterility: The pump dispenses product without touching the container’s interior.

Nyoteni formulation

Our formulation is an elegant oil-in-water vanishing cream formulated for enhanced transdermal penetration with added emollients providing a better rubin and longer-lasting moisturization without irritation. The ideal carrier conditions for exosomes to have a high rate of viable efficacy and skin penetration.

Why apply at night?

Nyoteni exosome night cream is formulated for maximum effect during nighttime sleep due to several reasons:

•⁠ ⁠Increased skin permeability: Skin’s natural barrier function decreases at night, allowing exosomes to penetrate deeper.
•⁠ ⁠Optimized skin pH: Nighttime skin pH balances, allowing exosomesir processes, and exosomes support this regeneration.
•⁠ ⁠Improved hydration: Nighttime skin hydration levels are higher, facilitating exosome absorption.
•⁠ ⁠Reduced environmental stressors: Nighttime protects skin from daily environmental damage (UV, pollution).
•⁠ ⁠Increased growth factor release: Sleep stimulates growth factor production, complementing exosome benefits.
•⁠ ⁠Better skin-lipid regulation: Exosomes support nighttime lipid regulation, essential for skin health.
•⁠ ⁠Enhanced detoxification: Sleep aids lymphatic drainage, and exosomes facilitate removal of toxins.
•⁠ ⁠Optimized skin pH: Nighttime skin pH balances, allowing exosomes to work efficiently.

To maximize results:

Apply Nyoteni's cream before bed

Maintain consistent sleep schedule

Combine with daytime skincare routine

Avoid harsh products

Get 7-8 hours of sleep

Added benefits:

⁠•⁠ ⁠Free of BHT, EDTA, Parabens & Urea
•⁠ ⁠enhanced penetration capability – efficacious exosome absorption
•⁠ ⁠Validated transdermal penetration
•⁠ ⁠Natural ingredients – less irritation than PLO
•⁠ ⁠Cosmetically elegant – lasting moisturizing effect
•⁠ ⁠Applies easily – no sticky residue

Our Lab is FDA registered and CGTP compliant (Current Good Tissue Practice) located in the USA. With our team of biotech experts exceeding over 20 years in experience in pharmaceutical and medical pathways we have committed to establishing superior quality control protocols to guarantee product safety and efficacy. We process in small batches in order to guarantee “freshness” and “viability”. Every order is handled with the utmost care and meticulously screened.

Out lab is equipped with high standardization technology (HST) with a modular clean room which is above ISO 6 classification requirements ensuring a superb sterile environment thus maximizing sterile product free of any contamination risks.